The names of victims have not yet been released, Roanoke Rapids police Chief Chuck Hasty said.
The single-vehicle crashed occurred around 11:30 p.m. near Gregory Drive when the driver of the vehicle apparently lost control and struck a tree in front of Fresenius Medical building, Hasty said a preliminary report by Officer A. Green shows.
Both men were trapped inside and Roanoke Valley Rescue, Roanoke Rapids Fire Department along with Halifax County EMS worked to extricate the victims from the vehicle.
One was deceased and the other was transported locally for treatment before being transferred.
Speed and alcohol use reportedly played a factor.
The North Carolina State Highway Patrol is assisting.