The severity of the injuries was not immediately known and Gaston Volunteer Fire Department Chief Ed Porter Jr. said investigation to determine the cause of the fire is ongoing. A second occupant escaped without injury.
The call came in shortly after 10 p.m. at 302 Gardner Drive.
Gaston and Garysburg firefighters responded to the single-story, cinder block house and observed flames and heavy smoke coming from the right side of the back of the house.
Porter said the fire appeared to start in a back bedroom. Firefighters got the fire under control in about 10 minutes, containing it to a single room.
Firefighters were assisted by the Gaston Police Department, Northampton County Sheriff's Office and Northampton EMS.
Additional details will be released later.