An autopsy will be performed to determine whether any medical issues play a part in the matter.
Trooper Scott Richardson said earlier today the man died as he drove his pickup south in the right northbound lane of Interstate 95.
Richardson said authorities received a call about a vehicle traveling south in the northbound lane of the interstate.
Less than five minutes later, the Highway Patrol received a call there was a collision between the pickup and a tractor-trailer.
EMS arrived and determined the driver of the pickup was deceased.