Dexter Devon Taylor, 22, is wanted for the murder of Jarshamel Cambridge, who was pronounced dead at Vidant Medical Center in Greenville following the shooting.
The shooting, Halifax County Sheriff Wes Tripp said in a statement, occurred near Freedom and Franklin streets in Enfield around 10:30.
Investigation by the sheriff's office led to Taylor being named in the murder warrant.
More arrests are expected, Tripp said this afternoon.
Anyone with information is encouraged to call the sheriff's office at 252-583-8201 or Crimestoppers at 252-583-4444.